Publication: Vaccination with nanoparticles combined with micro-adjuvants protects against cancer
Vaccination with nanoparticles combined with micro-adjuvants protects against cancer
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Mohsen, M. O., Heath, M. D., Cabral-Miranda, G., Lipp, C., Zeltins, A., Sande, M., Stein, J. V., Riether, C., Roesti, E., Zha, L., Engeroff, P., El-Turabi, A., Kundig, T. M., Vogel, M., Skinner, M. A., Speiser, D. E., Knuth, A., Kramer, M. F., & Bachmann, M. F. (2019). Vaccination with nanoparticles combined with micro-adjuvants protects against cancer. Journal for ImmunoTherapy of Cancer, 7(1), 114. https://doi.org/10.1186/s40425-019-0587-z
Abstract
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Abstract
BACKGROUND
Induction of strong T cell responses, in particular cytotoxic T cells, is a key for the generation of efficacious therapeutic cancer vaccines which yet, remains a major challenge for the vaccine developing world. Here we demonstrate that it is possible to harness the physiological properties of the lymphatic system to optimize the induction of a protective T cell response. Indeed, the lymphatic system sharply distinguishes between nanoscale and microscale particles. The former reaches the fenestrated lymphatic system via d
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Creators (Authors)
- Mohsen, Mona O
- Heath, Matthew D
- Cabral-Miranda, Gustavo
- Lipp, Cyrill
- Zeltins, Andris
- Sande, Marcos
- Stein, Jens V
- Riether, Carsten
- Roesti, Elisa
- Zha, Lisha
- El-Turabi, Aadil
- Kundig, Thomas M
- Vogel, Monique
- Skinner, Murray A
- Speiser, Daniel E
- Knuth, Alexander
- Kramer, Matthias F
- Bachmann, Martin F
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Mohsen, M. O., Heath, M. D., Cabral-Miranda, G., Lipp, C., Zeltins, A., Sande, M., Stein, J. V., Riether, C., Roesti, E., Zha, L., Engeroff, P., El-Turabi, A., Kundig, T. M., Vogel, M., Skinner, M. A., Speiser, D. E., Knuth, A., Kramer, M. F., & Bachmann, M. F. (2019). Vaccination with nanoparticles combined with micro-adjuvants protects against cancer. Journal for ImmunoTherapy of Cancer, 7(1), 114. https://doi.org/10.1186/s40425-019-0587-z
