Publication: Glycoprotein (GP)96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity
Glycoprotein (GP)96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity
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Häfliger, J., Schwarzfischer, M., Atrott, K., Stanzel, C., Morsy, Y., Wawrzyniak, M., Lang, S., Valenta, T., Basler, K., Rogler, G., Scharl, M., & Spalinger, M. R. (2023). Glycoprotein (GP)96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity. Cellular and Molecular Gastroenterology and Hepatology, 15, 717–739. https://doi.org/10.1016/j.jcmgh.2022.12.004
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BACKGROUND & AIMS
Glycoprotein (GP)96 is an endoplasmic reticulum (ER)-resident master chaperone for cell surface receptors including the Wnt co-receptors LRP5/6. Intestinal epithelial cells (IEC)-specific deletion of Gp96 is embryonically lethal. However, the role of GP96 in adult intestinal tissue and especially within the intestinal stem cell (ISC) niche has not been studied so far. Here, we investigated how GP96-loss interferes with intestinal homeostasis by compromising viability, proliferation and differentiation of IEC.
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Häfliger, J., Schwarzfischer, M., Atrott, K., Stanzel, C., Morsy, Y., Wawrzyniak, M., Lang, S., Valenta, T., Basler, K., Rogler, G., Scharl, M., & Spalinger, M. R. (2023). Glycoprotein (GP)96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity. Cellular and Molecular Gastroenterology and Hepatology, 15, 717–739. https://doi.org/10.1016/j.jcmgh.2022.12.004
