Publication: Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
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Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., & Hafen, E. (2003). Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nature Cell Biology, 5, 559–565. https://doi.org/10.1038/ncb995
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Understanding the mechanisms through which multicellular organisms regulate cell, organ and body growth is of relevance to developmental biology and to research on growth-related diseases such as cancer. Here we describe a new effector in growth control, the small GTPase Rheb (Ras homologue enriched in brain). Mutations in the Drosophila melanogaster Rheb gene were isolated as growth-inhibitors, whereas overexpression of Rheb promoted cell growth. Our genetic and biochemical analyses suggest that Rheb functions downstream of the tumou
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- Stocker, H
- Radimerski, T
- Wittwer, F
- Belawat, P
- Thomas, G
- Hafen, E
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Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., & Hafen, E. (2003). Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nature Cell Biology, 5, 559–565. https://doi.org/10.1038/ncb995
