Publication: Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
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Vasilevska, J., Cheng, P. F., Lehmann, J., Ramelyte, E., Gómez, J. M., Dimitriou, F., Sella, F., TuPro Consortium, Ferretti, D., Salas-Bastos, A., Jordaan, W. S., Levesque, M. P., Dummer, R., & Sommer, L. (2024). Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance. Cell Reports Medicine, 5(7), 101611. https://doi.org/10.1016/j.xcrm.2024.101611
Abstract
Abstract
Abstract
Resistance to targeted therapy remains a major clinical challenge in melanoma. To uncover resistance mechanisms, we perform single-cell RNA sequencing on fine-needle aspirates from resistant and responding tumors of patients undergoing BRAFi/MEKi treatment. Among the genes most prominently expressed in resistant tumors is POSTN, predicted to signal to a macrophage population associated with targeted therapy resistance (TTR). Accordingly, tumors from patients with fast disease progression after therapy exhibit high POSTN expression lev
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Creators (Authors)
- Vasilevska, Jelena
- Lehmann, Julia
- Ramelyte, Egle
- Gómez, Julia Martínez
- Dimitriou, Florentia
- Sella, Federica
- Ferretti, Daria
- Salas-Bastos, Adrian
- Jordaan, Whitney Shannon
- Dummer, Reinhard
- Sommer, Lukas
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Vasilevska, J., Cheng, P. F., Lehmann, J., Ramelyte, E., Gómez, J. M., Dimitriou, F., Sella, F., TuPro Consortium, Ferretti, D., Salas-Bastos, A., Jordaan, W. S., Levesque, M. P., Dummer, R., & Sommer, L. (2024). Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance. Cell Reports Medicine, 5(7), 101611. https://doi.org/10.1016/j.xcrm.2024.101611
