Publication: 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development
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Wang, T., Wang, Z., de Fabritus, L., Tao, J., Saied, E. M., Lee, H.-J., Ramazanov, B. R., Jackson, B., Burkhardt, D., Parker, M., Gleinich, A. S., Wang, Z., Seo, D. E., Zhou, T., Xu, S., Alecu, I., Azadi, P., Arenz, C., Hornemann, T., … Santori, F. R. (2021). 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. Developmental Cell, 56, 3128-3145.e15. https://doi.org/10.1016/j.devcel.2021.10.018
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Identification of physiological modulators of nuclear hormone receptor (NHR) activity is paramount for understanding the link between metabolism and transcriptional networks that orchestrate development and cellular physiology. Using libraries of metabolic enzymes alongside their substrates and products, we identify 1-deoxysphingosines as modulators of the activity of NR2F1 and 2 (COUP-TFs), which are orphan NHRs that are critical for development of the nervous system, heart, veins, and lymphatic vessels. We show that these non-canoni
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Creators (Authors)
- Wang, Ting
- Wang, Zheng
- de Fabritus, Lauriane
- Tao, Jinglian
- Saied, Essa M
- Lee, Ho-Joon
- Ramazanov, Bulat R
- Jackson, Benjamin
- Burkhardt, Daniel
- Parker, Mikhail
- Gleinich, Anne S
- Wang, Zhirui
- Seo, Dong Eun
- Zhou, Ting
- Xu, Shihao
- Alecu, Irina
- Azadi, Parastoo
- Arenz, Christoph
- Hornemann, Thorsten
- Krishnaswamy, Smita
- van de Pavert, Serge A
- Kaech, Susan M
- Ivanova, Natalia B
- Santori, Fabio R
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Wang, T., Wang, Z., de Fabritus, L., Tao, J., Saied, E. M., Lee, H.-J., Ramazanov, B. R., Jackson, B., Burkhardt, D., Parker, M., Gleinich, A. S., Wang, Z., Seo, D. E., Zhou, T., Xu, S., Alecu, I., Azadi, P., Arenz, C., Hornemann, T., … Santori, F. R. (2021). 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. Developmental Cell, 56, 3128-3145.e15. https://doi.org/10.1016/j.devcel.2021.10.018