Publication: Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity.
Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity.
Date
Date
Date
Citations
Fendt, S.-M., Buescher, J. M., Rudroff, F., Picotti, P., Zamboni, N., & Sauer, U. (2010). Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity. Molecular Systems Biology, 6, 356. https://doi.org/10.1038/msb.2010.11
Abstract
Abstract
Abstract
What is the relationship between enzymes and metabolites, the two major constituents of metabolic networks? We propose three alternative relationships between enzyme capacity and metabolite concentration alterations based on a Michaelis-Menten kinetic; that is enzyme capacities, metabolite concentrations, or both could limit the metabolic reaction rates. These relationships imply different correlations between changes in enzyme capacity and metabolite concentration, which we tested by quantifying metabolite, transcript, and enzyme abu
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Fendt, Sarah-Maria
- Buescher, Joerg Martin
- Rudroff, Florian
- Picotti, Paola
- Zamboni, Nicola
- Sauer, Uwe
Volume
Volume
Volume
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Fendt, S.-M., Buescher, J. M., Rudroff, F., Picotti, P., Zamboni, N., & Sauer, U. (2010). Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity. Molecular Systems Biology, 6, 356. https://doi.org/10.1038/msb.2010.11
