WNT/β-Catenin Signaling Promotes TGF-β-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production

Działo, Edyta; Czepiel, Marcin; Tkacz, Karolina; Siedlar, Maciej; Kania, Gabriela; Błyszczuk, Przemysław

doi:10.3390/ijms221810072

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Działo, E., Czepiel, M., Tkacz, K., Siedlar, M., Kania, G., & Błyszczuk, P. (2021). WNT/β-Catenin Signaling Promotes TGF-β-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production. International Journal of Molecular Sciences, 22(18), 10072. https://doi.org/10.3390/ijms221810072

Abstract

Cardiac fibrosis is a pathological process associated with the development of heart failure. TGF-β and WNT signaling have been implicated in pathogenesis of cardiac fibrosis, however, little is known about molecular cross-talk between these two pathways. The aim of this study was to examine the effect of exogenous canonical WNT3a and non-canonical WNT5a in TGF-β-activated human cardiac fibroblasts. We found that WNT3a and TGF-β induced a β-catenin-dependent response, whereas WNT5a prompted AP-1 activity. TGF-β triggered profibrotic si