Publication: Functional Implications of Genetic Polymorphisms in the Multidrug Resistance Gene MDR1 (ABCB1)
Functional Implications of Genetic Polymorphisms in the Multidrug Resistance Gene MDR1 (ABCB1)
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Pauli-Magnus, C., & Kroetz, D. L. (2004). Functional Implications of Genetic Polymorphisms in the Multidrug Resistance Gene MDR1 (ABCB1). Pharmaceutical Research, 21, 904–913. https://doi.org/10.1023/b:pham.0000029276.21063.0b
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The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane protein that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous substrates from the inside of cells to the outside. Physiological expression of P-glycoprotein in tissues with excretory or protective function is a major determinant of drug disposition and provides a cellular defense mechanism against potentially harmful compounds. Therefore, P-glycoprotein has significant impact on therapeutic efficacy and toxicity as it plays a key
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- Pauli-Magnus, Christiane
- Kroetz, Deanna L
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Pauli-Magnus, C., & Kroetz, D. L. (2004). Functional Implications of Genetic Polymorphisms in the Multidrug Resistance Gene MDR1 (ABCB1). Pharmaceutical Research, 21, 904–913. https://doi.org/10.1023/b:pham.0000029276.21063.0b
