Sex differences in Alzheimer disease - the gateway to precision medicine

Ferretti, Maria Teresa; Iulita, Maria Florencia; Cavedo, Enrica; Chiesa, Patrizia Andrea; Schumacher Dimech, Annemarie; Santuccione Chadha, Antonella; Baracchi, Francesca; Girouard, Hélène; Misoch, Sabina; Giacobini, Ezio; Depypere, Herman; Hampel, Harald

doi:10.1038/s41582-018-0032-9

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Ferretti, M. T., Iulita, M. F., Cavedo, E., Chiesa, P. A., Schumacher Dimech, A., Santuccione Chadha, A., Baracchi, F., Girouard, H., Misoch, S., Giacobini, E., Depypere, H., & Hampel, H. (2018). Sex differences in Alzheimer disease - the gateway to precision medicine. Nature Reviews. Neurology, 14(8), 457–469. https://doi.org/10.1038/s41582-018-0032-9

Abstract

Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic variation will be crucial for the development of precise and effective therapeutics in AD. Sex-related differences in neural anatomy and function are starting to emerge, and sex might constitute an important factor for AD patient stratification and personalized treatment. Although the effects of sex on AD epidemiology are currently the subject of intense invest