Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state

Werdermann, Martin; Berger, Ilona; Scriba, Laura D; Santambrogio, Alice; Schlinkert, Pia; Brendel, Heike; Morawietz, Henning; Schedl, Andreas; Peitzsch, Mirko; King, Aileen J F; Andoniadou, Cynthia L; Bornstein, Stefan R; Steenblock, Charlotte

doi:10.1016/j.molmet.2020.101112

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Werdermann, M., Berger, I., Scriba, L. D., Santambrogio, A., Schlinkert, P., Brendel, H., Morawietz, H., Schedl, A., Peitzsch, M., King, A. J. F., Andoniadou, C. L., Bornstein, S. R., & Steenblock, C. (2021). Insulin and obesity transform hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state. Molecular Metabolism, 43, 101112. https://doi.org/10.1016/j.molmet.2020.101112

Abstract

OBJECTIVE

Metabolic diseases are an increasing problem in society with the brain-metabolic axis as a master regulator of the human body for sustaining homeostasis under metabolic stress. However, metabolic inflammation and disease will trigger sustained activation of the hypothalamic-pituitary-adrenal axis. In this study, we investigated the role of metabolic stress on progenitor cells in the hypothalamic-pituitary-adrenal axis.

METHODS

In vitro, we applied insulin and leptin to murine progenitor cells isolated from the pituitary a