Publication:

A novel method for automated crystal visualization and quantification in murine folic acid-induced acute kidney injury

Date

Date

Date
2024
Journal Article
Published version
Simple data Full metadata Statistics
cris.lastimport.scopus2025-06-24T03:50:13Z
cris.lastimport.wos2025-07-29T01:33:30Z
dc.contributor.institutionUniversity of Zurich
dc.date.accessioned2024-02-08T10:28:23Z
dc.date.available2024-02-08T10:28:23Z
dc.date.issued2024-01-01
dc.description.abstract

Here, we describe a novel method for the visualization and quantification of renal folic acid (FA) crystals in the rodent FA-induced acute kidney injury (FA-AKI) model. The protocol involves a straightforward histological approach followed by fully automated imaging and quantification steps. Applicability was confirmed by showing that the FA-AKI model is sex-dependent. The method can serve as a tool to aid in characterizing FA-AKI and to control for studies investigating prophylactic therapeutic avenues using FA-AKI.

dc.identifier.doi10.1152/ajprenal.00140.2023
dc.identifier.issn1522-1466
dc.identifier.scopus2-s2.0-85181250976
dc.identifier.urihttps://www.zora.uzh.ch/handle/20.500.14742/216302
dc.identifier.wos001141880200001
dc.language.isoeng
dc.subjectPhysiology
dc.subject.ddc610 Medicine & health
dc.subject.ddc570 Life sciences; biology
dc.title

A novel method for automated crystal visualization and quantification in murine folic acid-induced acute kidney injury

dc.typearticle
dcterms.accessRightsinfo:eu-repo/semantics/openAccess
dcterms.bibliographicCitation.journaltitleAmerican Journal of Physiology : Renal Physiology
dcterms.bibliographicCitation.number1
dcterms.bibliographicCitation.originalpublishernameAmerican Physiological Society
dcterms.bibliographicCitation.pageendF117
dcterms.bibliographicCitation.pagestartF105
dcterms.bibliographicCitation.pmid37881875
dcterms.bibliographicCitation.volume326
dspace.entity.typePublicationen
uzh.contributor.affiliationUniversity of Zurich, National Center of Competence in Research NCCR Kidney.CH
uzh.contributor.affiliationUniversity of Zurich, National Center of Competence in Research NCCR Kidney.CH
uzh.contributor.affiliationETH Zürich
uzh.contributor.affiliationUniversity of Zurich, National Center of Competence in Research NCCR Kidney.CH
uzh.contributor.affiliationUniversity of Zurich, National Center of Competence in Research NCCR Kidney.CH
uzh.contributor.authorHamid, Ahmad Kamal
uzh.contributor.authorPastor Arroyo, Eva Maria
uzh.contributor.authorLee, Sung Sik
uzh.contributor.authorWagner, Carsten Alexander
uzh.contributor.authorEgli-Spichtig, Daniela
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceNo
uzh.contributor.correspondenceYes
uzh.document.availabilitypostprint
uzh.document.availabilitypublished_version
uzh.eprint.datestamp2024-02-08 10:28:23
uzh.eprint.lastmod2025-07-29 01:56:10
uzh.eprint.statusChange2024-02-08 10:28:23
uzh.funder.nameGottfried und Julia Bangerter-Rhyner-Stiftung
uzh.funder.nameOlga Mayenfisch Stiftung
uzh.funder.nameSNF | Swiss National Centre of Competence in Research Kidney Control of Homeostasis
uzh.harvester.ethYes
uzh.harvester.nbNo
uzh.identifier.doi10.5167/uzh-255714
uzh.jdb.eprintsId15781
uzh.oastatus.unpaywallclosed
uzh.oastatus.zoraHybrid
uzh.publication.citationHamid, Ahmad Kamal; Pastor Arroyo, Eva Maria; Lee, Sung Sik; Wagner, Carsten Alexander; Egli-Spichtig, Daniela (2024). A novel method for automated crystal visualization and quantification in murine folic acid-induced acute kidney injury. American Journal of Physiology : Renal Physiology, 326(1):F105-F117.
uzh.publication.freeAccessAtdoi
uzh.publication.originalworkoriginal
uzh.publication.publishedStatusfinal
uzh.scopus.impact3
uzh.scopus.subjectsPhysiology
uzh.scopus.subjectsUrology
uzh.workflow.doajuzh.workflow.doaj.false
uzh.workflow.eprintid255714
uzh.workflow.fulltextStatuspublic
uzh.workflow.revisions66
uzh.workflow.rightsCheckkeininfo
uzh.workflow.sourceCrossref:10.1152/ajprenal.00140.2023
uzh.workflow.statusarchive
uzh.wos.impact3
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