Publication: Phosphodiesterase-4 Inhibition Reduces Cutaneous Inflammation and IL-1β Expression in a Psoriasiform Mouse Model but Does Not Inhibit Inflammasome Activation
Phosphodiesterase-4 Inhibition Reduces Cutaneous Inflammation and IL-1β Expression in a Psoriasiform Mouse Model but Does Not Inhibit Inflammasome Activation
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Meier-Schiesser, B., Mellett, M., Ramirez-Fort, M. K., Maul, J.-T., Klug, A., Winkelbeiner, N., Fenini, G., Schafer, P., Contassot, E., & French, L. E. (2021). Phosphodiesterase-4 Inhibition Reduces Cutaneous Inflammation and IL-1β Expression in a Psoriasiform Mouse Model but Does Not Inhibit Inflammasome Activation. International Journal of Molecular Sciences, 22(23), 12878. https://doi.org/10.3390/ijms222312878
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Apremilast (Otezla®) is an oral small molecule phosphodiesterase 4 (PDE4) inhibitor approved for the treatment of psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet’s disease. While PDE4 inhibition overall is mechanistically understood, the effect of apremilast on the innate immune response, particularly inflammasome activation, remains unknown. Here, we assessed the effect of apremilast in a psoriasis mouse model and primary human cells. Psoriatic lesion development in vivo was studied in K5.Stat3C transgenic mice
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- Meier-Schiesser, Barbara
- Ramirez-Fort, Marigdalia K
- Maul, Julia-Tatjana
- Klug, Annika
- Winkelbeiner, Nicola
- Fenini, Gabriele
- Schafer, Peter
- Contassot, Emmanuel
- French, Lars E
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Meier-Schiesser, B., Mellett, M., Ramirez-Fort, M. K., Maul, J.-T., Klug, A., Winkelbeiner, N., Fenini, G., Schafer, P., Contassot, E., & French, L. E. (2021). Phosphodiesterase-4 Inhibition Reduces Cutaneous Inflammation and IL-1β Expression in a Psoriasiform Mouse Model but Does Not Inhibit Inflammasome Activation. International Journal of Molecular Sciences, 22(23), 12878. https://doi.org/10.3390/ijms222312878
