Publication: HSV-1 amplicon vectors launch the production of heterologous Rotavirus-like particles and induce Rotavirus-specific immune responses in mice
HSV-1 amplicon vectors launch the production of heterologous Rotavirus-like particles and induce Rotavirus-specific immune responses in mice
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Laimbacher, A. S., Esteban, L. E., Castello, A. A., Abdusetir Cerfoglio, J. C., Argüelles, M. H., Glikmann, G., D’Antuono, A., Mattion, N., Berois, M., Arbiza, J., Hilbe, M., Schraner, E. M., Seyffert, M., Dresch, C., Epstein, A. L., Ackermann, M., & Fraefel, C. (2012). HSV-1 amplicon vectors launch the production of heterologous Rotavirus-like particles and induce Rotavirus-specific immune responses in mice. Molecular Therapy, 20(9), 1810–1820. https://doi.org/10.1038/mt.2012.108
Abstract
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Virus-like particles (VLPs) are promising vaccine candidates because they represent viral antigens in the authentic conformation of the virion and are therefore readily recognized by the immune system. As VLPs do not contain genetic material they are safer than attenuated virus vaccines. In this study, herpes simplex virus type 1 (HSV-1) amplicon vectors were constructed to coexpress the rotavirus (RV) structural genes VP2, VP6, and VP7 and were used as platforms to launch the production of RV-like particles (RVLPs) in vector-infected
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- Laimbacher, Andrea S
- Esteban, Laura E
- Castello, Alejandro A
- Abdusetir Cerfoglio, Juan C
- Argüelles, Marcelo H
- Glikmann, Graciela
- D'Antuono, Alejandra
- Mattion, Nora
- Berois, Mabel
- Arbiza, Juan
- Hilbe, Monika
- Schraner, Elisabeth M
- Dresch, Christiane
- Epstein, Alberto L
- Ackermann, Mathias
- Fraefel, Cornel
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Laimbacher, A. S., Esteban, L. E., Castello, A. A., Abdusetir Cerfoglio, J. C., Argüelles, M. H., Glikmann, G., D’Antuono, A., Mattion, N., Berois, M., Arbiza, J., Hilbe, M., Schraner, E. M., Seyffert, M., Dresch, C., Epstein, A. L., Ackermann, M., & Fraefel, C. (2012). HSV-1 amplicon vectors launch the production of heterologous Rotavirus-like particles and induce Rotavirus-specific immune responses in mice. Molecular Therapy, 20(9), 1810–1820. https://doi.org/10.1038/mt.2012.108
