Publication: HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other
HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other
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Tasara, T., Maga, G., Hottiger, M. O., & Hübscher, U. (2001). HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. FEBS Letters, 507(1), 39–44. https://doi.org/10.1016/S0014-5793(01)02945-3
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Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzymes within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication with
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- Tasara, T
- Maga, G
- Hottiger, M O
- Hübscher, U
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Tasara, T., Maga, G., Hottiger, M. O., & Hübscher, U. (2001). HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other. FEBS Letters, 507(1), 39–44. https://doi.org/10.1016/S0014-5793(01)02945-3