Publication: Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis
Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis
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Meier-Schiesser, B., Feldmeyer, L., Jankovic, D., Mellett, M., Satoh, T. K., Yerly, D., Navarini, A., Abe, R., Yawalkar, N., Chung, W.-H., French, L. E., & Contassot, E. (2019). Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis. Journal of Investigative Dermatology, 139, 848–858. https://doi.org/10.1016/j.jid.2018.10.023
Abstract
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Abstract
Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous drug reaction. Although an involvement of drug-specific T cells has been reported, the physiopathology of AGEP and mechanism of neutrophilic skin inflammation remain incompletely understood. Recently, mutations in IL-36RN, the gene encoding the IL-36 receptor antagonist, have been reported to be more frequent in AGEP patients and pustular psoriasis. Here, we show that IL-36 cytokines, in particular IL-36γ, are highly expressed in lesional skin of AGEP pati
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- Meier-Schiesser, Barbara
- Feldmeyer, Laurence
- Jankovic, Dragana
- Satoh, Takashi K
- Yerly, Daniel
- Navarini, Alexander
- Abe, Riichiro
- Yawalkar, Nikhil
- Chung, Wen-Hung
- French, Lars E
- Contassot, Emmanuel
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Meier-Schiesser, B., Feldmeyer, L., Jankovic, D., Mellett, M., Satoh, T. K., Yerly, D., Navarini, A., Abe, R., Yawalkar, N., Chung, W.-H., French, L. E., & Contassot, E. (2019). Culprit Drugs Induce Specific IL-36 Overexpression in Acute Generalized Exanthematous Pustulosis. Journal of Investigative Dermatology, 139, 848–858. https://doi.org/10.1016/j.jid.2018.10.023
