Publication: Anti-chlamydial effects of azelastine hydrochloride and the impact of the histamine H1 receptor on chlamydial development
Anti-chlamydial effects of azelastine hydrochloride and the impact of the histamine H1 receptor on chlamydial development
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Kuratli, J., Leonard, C. A., Schoborg, R., & Borel, N. (2023). Anti-chlamydial effects of azelastine hydrochloride and the impact of the histamine H1 receptor on chlamydial development. Journal of Medical Microbiology, 72, 001691. https://doi.org/10.1099/jmm.0.001691
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Abstract
Introduction: Azelastine hydrochloride, a second-generation histamine H1 receptor (H1R) antagonist, exhibits anti-chlamydial effects against Chlamydia trachomatis (CT) in HeLa cells (genital infection model). Hypothesis/Gap Statement: Non-antibiotic pharmaceutical interactions with CT are an understudied field and the anti-chlamydial effects of azelastine are a potential interaction requiring further elucidation. Aim: To explore the underlying anti-chlamydial mechanisms of azelastine. Methodology: We assessed the specificity of azelas
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- Kuratli, Jasmin
- Leonard, Cory Ann
- Schoborg, Robert
- Borel, Nicole
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Kuratli, J., Leonard, C. A., Schoborg, R., & Borel, N. (2023). Anti-chlamydial effects of azelastine hydrochloride and the impact of the histamine H1 receptor on chlamydial development. Journal of Medical Microbiology, 72, 001691. https://doi.org/10.1099/jmm.0.001691
