Publication: Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli
Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli
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Aguilar-Rodríguez, J., Fares, M. A., & Wagner, A. (2019). Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli. FEMS Microbiology Letters, 366(10), fnz121. https://doi.org/10.1093/femsle/fnz121
Abstract
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Abstract
Bacterial cells adapting to a constant environment tend to accumulate mutations in portions of their genome that are not maintained by selection. This process has been observed in bacteria evolving under strong genetic drift, and especially in bacterial endosymbionts of insects. Here, we study this process in hypermutable Escherichia coli populations evolved through 250 single-cell bottlenecks on solid rich medium in a mutation accumulation experiment that emulates the evolution of bacterial endosymbionts. Using phenotype microarrays
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- Aguilar-Rodríguez, José
- Fares, Mario A
- Wagner, Andreas
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Aguilar-Rodríguez, J., Fares, M. A., & Wagner, A. (2019). Chaperonin overproduction and metabolic erosion caused by mutation accumulation in Escherichia coli. FEMS Microbiology Letters, 366(10), fnz121. https://doi.org/10.1093/femsle/fnz121
