Publication: Cancer T cell immunotherapy with bispecific antibodies and chimeric antigen receptors
Cancer T cell immunotherapy with bispecific antibodies and chimeric antigen receptors
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Lacher, M. D., & Provenzano, M. (2013). Cancer T cell immunotherapy with bispecific antibodies and chimeric antigen receptors. Recent Patents on Anti-Cancer Drug Discovery, 8(3), 239–254. https://doi.org/10.2174/15748928113088880003
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Solid tumors contain several different types of malignant cells. This cellular heterogeneity complicates therapy for at least two reasons. First, each subpopulation may respond differently to a given treatment. Second, cancer cells are plastic, and thus may convert from a therapy-sensitive to a therapy-resistant cell type represented by another subpopulation. Therefore, successful therapies will have to target numerous malignant cell types, not just the rapidly proliferating cells as most standard treatments do. Immunotherapies with T
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- Lacher, Markus D
- Provenzano, Maurizio
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Lacher, M. D., & Provenzano, M. (2013). Cancer T cell immunotherapy with bispecific antibodies and chimeric antigen receptors. Recent Patents on Anti-Cancer Drug Discovery, 8(3), 239–254. https://doi.org/10.2174/15748928113088880003