Publication: Prolidase is required for early trafficking events during influenza a virus entry
Prolidase is required for early trafficking events during influenza a virus entry
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Pohl, M. O., Edinger, T. O., & Stertz, S. (2014). Prolidase is required for early trafficking events during influenza a virus entry. Journal of Virology, 88(19), 11271–11283. https://doi.org/10.1128/JVI.00800-14
Abstract
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Abstract
Influenza A virus (IAV) entry is a multistep process that requires the interaction of the virus with numerous host factors. In this study, we demonstrate that prolidase (PEPD) is a cellular factor required by IAV for successful entry into target cells. PEPD was selected as a candidate during an entry screen performed on nonvalidated primary hits from previously published genome-wide small interfering RNA (siRNA) screens. siRNA-mediated depletion of PEPD resulted in the decreased growth of IAV during mono- and multicycle growth. This g
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- Pohl, M O
- Edinger, T O
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Pohl, M. O., Edinger, T. O., & Stertz, S. (2014). Prolidase is required for early trafficking events during influenza a virus entry. Journal of Virology, 88(19), 11271–11283. https://doi.org/10.1128/JVI.00800-14
