Publication: Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses
Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses
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Müller, J. M. V., Feige, K., Wunderlin, P., Hödl, A., Meli, M. L., Seltenhammer, M., Grest, P., Nicolson, L., Schelling, C., & Heinzerling, L. M. (2011). Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses. Journal of Immunotherapy, 34, 58–64. https://doi.org/10.1097/CJI.0b013e3181fe1997
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Melanoma is a disease with high incidence in gray horses and has limited therapeutic options in metastatic disease. Gene therapy has shown some success in animal models and human patients. A randomized double-blind, placebo-controlled study was conducted to investigate 2 treatment options using cytokine-encoding plasmid DNA in horses with metastatic melanoma to induce immunologic antitumor effects. Adult gray horses with spontaneously occurring metastatic melanoma (n=26) were included in the study. Treatment of 26 gray horses with met
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Creators (Authors)
- Müller, J M V
- Feige, K
- Wunderlin, P
- Hödl, A
- Meli, M L
- Seltenhammer, M
- Grest, P
- Nicolson, L
- Schelling, C
- Heinzerling, L M
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Müller, J. M. V., Feige, K., Wunderlin, P., Hödl, A., Meli, M. L., Seltenhammer, M., Grest, P., Nicolson, L., Schelling, C., & Heinzerling, L. M. (2011). Double-blind placebo-controlled study with interleukin-18 and interleukin-12-encoding plasmid DNA shows antitumor effect in metastatic melanoma in gray horses. Journal of Immunotherapy, 34, 58–64. https://doi.org/10.1097/CJI.0b013e3181fe1997
