Publication: Accumulating evidence for a role of oxidized phospholipids in infectious diseases
Accumulating evidence for a role of oxidized phospholipids in infectious diseases
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Matt, U., Sharif, O., Martins, R., & Knapp, S. (2015). Accumulating evidence for a role of oxidized phospholipids in infectious diseases. Cellular and Molecular Life Sciences, 72(6), 1059–1071. https://doi.org/10.1007/s00018-014-1780-3
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Oxidized phospholipids (OxPL) were originally discovered as by-products and mediators of chronic inflammation such as in atherosclerosis. Over the last years, an increasing body of evidence led to the notion that OxPL not only contribute to the pathogenesis of chronic inflammatory processes but in addition play an integral role as modulators of inflammation during acute infections. Thereby, host defense mechanisms involve the generation of oxygen radicals that oxidize ubiquitously present phospholipids, which in turn act as danger-ass
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- Matt, Ulrich
- Sharif, Omar
- Martins, Rui
- Knapp, Sylvia
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Matt, U., Sharif, O., Martins, R., & Knapp, S. (2015). Accumulating evidence for a role of oxidized phospholipids in infectious diseases. Cellular and Molecular Life Sciences, 72(6), 1059–1071. https://doi.org/10.1007/s00018-014-1780-3