Publication: Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study
Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study
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Wnęk, M., Ressel, L., Ricci, E., Rodriguez-Martinez, C., Guerrero, J. C. V., Ismail, Z., Smith, C., Kipar, A., Sodeik, B., Chinnery, P. F., Solomon, T., & Griffiths, M. J. (2016). Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study. Acta Neuropathologica, 132, 433–451. https://doi.org/10.1007/s00401-016-1597-2
Abstract
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Abstract
Herpes simplex virus type-1 (HSV-1) encephalitis (HSE) is the most commonly diagnosed cause of viral encephalitis in western countries. Despite antiviral treatment, HSE remains a devastating disease with high morbidity and mortality. Improved understanding of pathogenesis may lead to more effective therapies. Mitochondrial damage has been reported during HSV infection in vitro. However, whether it occurs in the human brain and whether this contributes to the pathogenesis has not been fully explored. Minocycline, an antibiotic, has bee
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- Wnęk, Małgorzata
- Ressel, Lorenzo
- Ricci, Emanuele
- Rodriguez-Martinez, Carmen
- Guerrero, Julio Cesar Villalvazo
- Ismail, Zarini
- Smith, Colin
- Kipar, Anja
- Sodeik, Beate
- Chinnery, Patrick F
- Solomon, Tom
- Griffiths, Michael J
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Wnęk, M., Ressel, L., Ricci, E., Rodriguez-Martinez, C., Guerrero, J. C. V., Ismail, Z., Smith, C., Kipar, A., Sodeik, B., Chinnery, P. F., Solomon, T., & Griffiths, M. J. (2016). Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study. Acta Neuropathologica, 132, 433–451. https://doi.org/10.1007/s00401-016-1597-2
