Publication: Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
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Zerbi, V., Pagani, M., Markicevic, M., Matteoli, M., Pozzi, D., Fagiolini, M., Bozzi, Y., Galbusera, A., Scattoni, M. L., Provenzano, G., Banerjee, A., Helmchen, F., Basson, M. A., Ellegood, J., Lerch, J. P., Rudin, M., Gozzi, A., & Wenderoth, N. (2021). Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes. Molecular Psychiatry, 26, 7610–7620. https://doi.org/10.1038/s41380-021-01245-4
Abstract
Abstract
Abstract
Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly heterogeneous abnormalities in functional brain connectivity. However, the origin and significance of this phenomenon remain unclear. To unravel ASD connectopathy and relate it to underlying etiological heterogeneity, we carried out a bi-center cross-etiological investigation of fMRI-based connectivity in the mouse, in which specific ASD-relevant mutations can be isolated and modeled minimizing environmental contributions. By performing brain-wide connectivity
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- Zerbi, V
- Pagani, M
- Markicevic, M
- Matteoli, M
- Pozzi, D
- Fagiolini, M
- Bozzi, Y
- Galbusera, A
- Scattoni, M L
- Provenzano, G
- Banerjee, A
- Helmchen, F
- Basson, M A
- Ellegood, J
- Lerch, J P
- Rudin, M
- Gozzi, A
- Wenderoth, N
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Zerbi, V., Pagani, M., Markicevic, M., Matteoli, M., Pozzi, D., Fagiolini, M., Bozzi, Y., Galbusera, A., Scattoni, M. L., Provenzano, G., Banerjee, A., Helmchen, F., Basson, M. A., Ellegood, J., Lerch, J. P., Rudin, M., Gozzi, A., & Wenderoth, N. (2021). Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes. Molecular Psychiatry, 26, 7610–7620. https://doi.org/10.1038/s41380-021-01245-4
