Publication: Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity
Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity
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Thomson, B. R., Richter, H., Akeret, K., Buzzi, R. M., Anagnostakou, V., van Niftrik, C. H. B., Schwendinger, N., Kulcsar, Z., Kronen, P. W., Regli, L., Fierstra, J., Schaer, D. J., & Hugelshofer, M. (2023). Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity. Journal of Stroke and Cerebrovascular Diseases, 32, 106985. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.106985
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Objectives: Cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) may be one of the main drivers of secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Haptoglobin scavenging of CSF-Hb has been shown to mitigate cerebrovascular disruption. Using digital subtraction angiography (DSA) and blood oxygenation-level dependent cerebrovascular reactivity imaging (BOLD-CVR) the aim was to assess the acute toxic effect of CSF-Hb on cerebral blood flow and autoregulation, as well as to test the protective effects of haptog
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Thomson, B. R., Richter, H., Akeret, K., Buzzi, R. M., Anagnostakou, V., van Niftrik, C. H. B., Schwendinger, N., Kulcsar, Z., Kronen, P. W., Regli, L., Fierstra, J., Schaer, D. J., & Hugelshofer, M. (2023). Blood oxygenation-level dependent cerebrovascular reactivity imaging as strategy to monitor CSF-hemoglobin toxicity. Journal of Stroke and Cerebrovascular Diseases, 32, 106985. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.106985