Vitamin D and fracture prevention

Bischoff-Ferrari, Heike A

doi:10.1016/j.rdc.2012.03.010

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Bischoff-Ferrari, H. A. (2012). Vitamin D and fracture prevention. Rheumatic Disease Clinics of North America, 38, 107–113. https://doi.org/10.1016/j.rdc.2012.03.010

Abstract

Based on evidence from double-blind RCTs, vitamin D supplementation reduces falls and nonvertebral fractures, including those at the hip. However, this benefit is dose-dependent. According to 2 meta-analysis in 2009 of double-blind RCTs, no fall reduction was observed for a dose of less than 700 IU per day. A higher dose of 700 to 1000 IU supplemental vitamin D per day reduced falls by 19%. Similarly, no fracture reduction was observed for a received dose of 400 IU or less per day. A higher received dose of 482 to 770 IU supplemental