Publication: The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis
The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis
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Eichenberger, M., Schwander, T., Hüppi, S., Kreuzer, J., Mittl, P. R. E., Peccati, F., Jiménez-Osés, G., Naesby, M., & Buller, R. M. (2023). The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis. Nature Catalysis, 6(10), 927–938. https://doi.org/10.1038/s41929-023-01018-y
Abstract
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Abstract
Anthocyanins are ubiquitous plant pigments used in a variety of technological applications. Yet, after over a century of research, the penultimate biosynthetic step to anthocyanidins attributed to the action of leucoanthocyanidin dioxygenase has never been efficiently reconstituted outside plants, preventing the construction of heterologous cell factories. Through biochemical and structural analysis, here we show that anthocyanin-related glutathione transferases, currently implicated only in anthocyanin transport, catalyse an essentia
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- Eichenberger, Michael
- Schwander, Thomas
- Hüppi, Sean
- Kreuzer, Jan
- Mittl, Peer R E
- Peccati, Francesca
- Jiménez-Osés, Gonzalo
- Naesby, Michael
- Buller, Rebecca M
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Eichenberger, M., Schwander, T., Hüppi, S., Kreuzer, J., Mittl, P. R. E., Peccati, F., Jiménez-Osés, G., Naesby, M., & Buller, R. M. (2023). The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis. Nature Catalysis, 6(10), 927–938. https://doi.org/10.1038/s41929-023-01018-y
