Biophysical network models and the human connectome

Abstract

A core goal of human connectomics is to characterise the neural pathways that underlie brain function. This can be largely achieved noninvasively by inferring white matter connectivity using diffusion MRI data. However, there are challenges. First, diffusion tractography is blind to directed connections, or whether a connection is expressed functionally. Second, we need to be able to go beyond the characterization of anatomical pathways, to understand distributed brain function that results from them. In particular, we need to charact Show more