Publication: Mutational patterns and regulatory networks in epigenetic subgroups of meningioma
Mutational patterns and regulatory networks in epigenetic subgroups of meningioma
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Paramasivam, N., Hübschmann, D., Toprak, U. H., Ishaque, N., Neidert, M., Schrimpf, D., Stichel, D., Reuss, D., Sievers, P., Reinhardt, A., Wefers, A. K., Jones, D. T. W., Gu, Z., Werner, J., Uhrig, S., Wirsching, H.-G., Schick, M., Bewerunge-Hudler, M., Beck, K., … et al. (2019). Mutational patterns and regulatory networks in epigenetic subgroups of meningioma. Acta Neuropathologica, 138(2), 295–308. https://doi.org/10.1007/s00401-019-02008-w
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Abstract
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign 1-3, intermediate A and B, and malignant. Here, we set out to identify subgroup-specific mutational patterns and gene regulation. Whole genome sequencing was performed on 62 samples across all MCs and WHO grades from 62 patients with matched blood control, including 40 sporadic meningiomas and 22 meningiomas arising after radiation (Mrad). RNA sequencing was added for 18 of these
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- Paramasivam, Nagarajan
- Hübschmann, Daniel
- Toprak, Umut H
- Ishaque, Naveed
- Neidert, Marian
- Schrimpf, Daniel
- Stichel, Damian
- Reuss, David
- Sievers, Philipp
- Reinhardt, Annekathrin
- Wefers, Annika K
- Jones, David T W
- Gu, Zuguang
- Werner, Johannes
- Uhrig, Sebastian
- Wirsching, Hans-Georg
- Schick, Matthias
- Bewerunge-Hudler, Melanie
- Beck, Katja
- Brehmer, Stephanie
- Urbschat, Steffi
- Seiz-Rosenhagen, Marcel
- Hänggi, Daniel
- Herold-Mende, Christel
- Ketter, Ralf
- Eils, Roland
- Ram, Zvi
- Pfister, Stefan M
- Wick, Wolfgang
- Weller, Michael
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Paramasivam, N., Hübschmann, D., Toprak, U. H., Ishaque, N., Neidert, M., Schrimpf, D., Stichel, D., Reuss, D., Sievers, P., Reinhardt, A., Wefers, A. K., Jones, D. T. W., Gu, Z., Werner, J., Uhrig, S., Wirsching, H.-G., Schick, M., Bewerunge-Hudler, M., Beck, K., … et al. (2019). Mutational patterns and regulatory networks in epigenetic subgroups of meningioma. Acta Neuropathologica, 138(2), 295–308. https://doi.org/10.1007/s00401-019-02008-w
