Rapid Transient Transcriptional Adaptation to Hypergravity in Jurkat T Cells Revealed by Comparative Analysis of Microarray and RNA-Seq Data

Vahlensieck, Christian; Thiel, Cora S; Adelmann, Jan; Lauber, Beatrice A; Polzer, Jennifer; Ullrich, Oliver

doi:10.3390/ijms22168451

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Vahlensieck, C., Thiel, C. S., Adelmann, J., Lauber, B. A., Polzer, J., & Ullrich, O. (2021). Rapid Transient Transcriptional Adaptation to Hypergravity in Jurkat T Cells Revealed by Comparative Analysis of Microarray and RNA-Seq Data. International Journal of Molecular Sciences, 22(16), 8451. https://doi.org/10.3390/ijms22168451

Abstract

Cellular responses to micro- and hypergravity are rapid and complex and appear within the first few seconds of exposure. Transcriptomic analyses are a valuable tool to analyze these genome-wide cellular alterations. For a better understanding of the cellular dynamics upon altered gravity exposure, it is important to compare different time points. However, since most of the experiments are designed as endpoint measurements, the combination of cross-experiment meta-studies is inevitable. Microarray and RNA-Seq analyses are two of the ma