Rapid stress-induced transcriptomic changes in the brain depend on beta-adrenergic signaling

Roszkowski, Martin; Manuella, Francesca; von Ziegler, Lukas; Durán-Pacheco, Gonzalo; Moreau, Jean-Luc; Mansuy, Isabelle M; Bohacek, Johannes

doi:10.1016/j.neuropharm.2016.03.046

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Roszkowski, M., Manuella, F., von Ziegler, L., Durán-Pacheco, G., Moreau, J.-L., Mansuy, I. M., & Bohacek, J. (2016). Rapid stress-induced transcriptomic changes in the brain depend on beta-adrenergic signaling. Neuropharmacology, 107, 329–338. https://doi.org/10.1016/j.neuropharm.2016.03.046

Abstract

Acute exposure to stressful experiences can rapidly increase anxiety and cause neuropsychiatric disorders. The effects of stress result in part from the release of neurotransmitters and hormones, which regulate gene expression in different brain regions. The fast neuroendocrine response to stress is largely mediated by norepinephrine (NE) and corticotropin releasing hormone (CRH), followed by a slower and more sustained release of corticosterone. While corticosterone is an important regulator of gene expression, it is not clear which