Publication: Misdelivery at the nuclear pore complex-stopping a virus dead in its tracks
Misdelivery at the nuclear pore complex-stopping a virus dead in its tracks
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Flatt, J. W., & Greber, U. F. (2015). Misdelivery at the nuclear pore complex-stopping a virus dead in its tracks. Cells, 4(3), 277–296. https://doi.org/10.3390/cells4030277
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Many viruses deliver their genomes into the host cell's nucleus before they replicate. While onco-retroviruses and papillomaviruses tether their genomes to host chromatin upon mitotic breakdown of the nuclear envelope, lentiviruses, such as human immunodeficiency virus, adenoviruses, herpesviruses, parvoviruses, influenza viruses, hepatitis B virus, polyomaviruses, and baculoviruses deliver their genomes into the nucleus of post-mitotic cells. This poses the significant challenge of slipping a DNA or RNA genome past the nuclear pore c
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Flatt, J. W., & Greber, U. F. (2015). Misdelivery at the nuclear pore complex-stopping a virus dead in its tracks. Cells, 4(3), 277–296. https://doi.org/10.3390/cells4030277
