Publication: GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells
GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells
Date
Date
Date
Citations
Degirmenci, B., Valenta, T., Dimitrieva, S., Hausmann, G., & Basler, K. (2018). GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Nature, 558(7710), 449–453. https://doi.org/10.1038/s41586-018-0190-3
Abstract
Abstract
Abstract
Wnt-β-catenin signalling plays a pivotal role in the homeostasis of the intestinal epithelium by promoting stem cell renewal. In the small intestine, epithelial Paneth cells secrete Wnt ligands and thus adopt the function of the stem cell niche to maintain epithelial homeostasis. It is unclear which cells comprise the stem cell niche in the colon. Here we show that subepithelial mesenchymal GLI1-expressing cells form this essential niche. Blocking Wnt secretion from GLI1-expressing cells prevents colonic stem cell renewal in mice: the
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Degirmenci, Bahar
- Valenta, Tomas
- Dimitrieva, Slavica
- Hausmann, George
Volume
Volume
Volume
Number
Number
Number
Page Range
Page Range
Page Range
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Keywords
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Publisher DOI
Metrics
Downloads
Views
Citations
Degirmenci, B., Valenta, T., Dimitrieva, S., Hausmann, G., & Basler, K. (2018). GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells. Nature, 558(7710), 449–453. https://doi.org/10.1038/s41586-018-0190-3
