Publication: Small intestinal metabolism is central to whole-body insulin resistance
Small intestinal metabolism is central to whole-body insulin resistance
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Angelini, G., Salinari, S., Castagneto-Gissey, L., Bertuzzi, A., Casella-Mariolo, J., Ahlin, S., Boskoski, I., Gaggini, M., Raffaelli, M., Costamagna, G., Casella, G., Marini, P. L., Gastaldelli, A., Bornstein, S., & Mingrone, G. (2021). Small intestinal metabolism is central to whole-body insulin resistance. Gut, 70(6), 1098–1109. https://doi.org/10.1136/gutjnl-2020-322073
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OBJECTIVE
To assess the role of jejunum in insulin resistance in humans and in experimental animals.
DESIGN
Twenty-four subjects undergoing biliopancreatic diversion (BPD) or Roux-en-Y gastric bypass (RYGB) were enrolled. Insulin sensitivity was measured at baseline and at 1 week after surgery using oral glucose minimal model.We excluded the jejunum from intestinal continuity in pigs and created a jejunal loop with its vascular and nerve supply intact accessible from two cutaneous stomas, and reconnected the bowel with an end-to-en
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Angelini, G., Salinari, S., Castagneto-Gissey, L., Bertuzzi, A., Casella-Mariolo, J., Ahlin, S., Boskoski, I., Gaggini, M., Raffaelli, M., Costamagna, G., Casella, G., Marini, P. L., Gastaldelli, A., Bornstein, S., & Mingrone, G. (2021). Small intestinal metabolism is central to whole-body insulin resistance. Gut, 70(6), 1098–1109. https://doi.org/10.1136/gutjnl-2020-322073