Publication: Heterodimeric BMP-2/7 for nucleus pulposus regeneration-In vitro and ex vivo studies
Heterodimeric BMP-2/7 for nucleus pulposus regeneration-In vitro and ex vivo studies
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Li, Z., Lang, G., Karfeld-Sulzer, L. S., Mader, K. T., Richards, R. G., Weber, F. E., Sammon, C., Sacks, H., Yayon, A., Alini, M., & Grad, S. (2017). Heterodimeric BMP-2/7 for nucleus pulposus regeneration-In vitro and ex vivo studies. Journal of Orthopaedic Research, 35(1), 51–60. https://doi.org/10.1002/jor.23351
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Abstract
Intervertebral disc (IVD) degeneration is the leading trigger of low back pain, which causes disability and leads to enormous healthcare toll worldwide. Biological treatment with growth factors has evolved as potential therapy for IVD regeneration. Bone morphogenetic protein 2 (BMP-2) and BMP-7 have shown promise in this regard. In the current study, we evaluated the effect of BMP-2/7 heterodimer for disc regeneration both in vitro and in organ culture. Nucleus pulposus (NP) cells isolated from bovine caudal disc were cultured in a fi
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- Li, Zhen
- Lang, Gernot
- Karfeld-Sulzer, Lindsay S
- Mader, Kerstin T
- Richards, R Geoff
- Weber, Franz E
- Sammon, Chris
- Sacks, Hagit
- Yayon, Avner
- Alini, Mauro
- Grad, Sibylle
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Li, Z., Lang, G., Karfeld-Sulzer, L. S., Mader, K. T., Richards, R. G., Weber, F. E., Sammon, C., Sacks, H., Yayon, A., Alini, M., & Grad, S. (2017). Heterodimeric BMP-2/7 for nucleus pulposus regeneration-In vitro and ex vivo studies. Journal of Orthopaedic Research, 35(1), 51–60. https://doi.org/10.1002/jor.23351
