Publication: Extent of DNA 2-hydroxyethylation by N-nitrosomethylethylamine and N-nitrosodiethylamine in vivo
Extent of DNA 2-hydroxyethylation by N-nitrosomethylethylamine and N-nitrosodiethylamine in vivo
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von Hofe, E., Kleihues, P., & Keefer, L. K. (1986). Extent of DNA 2-hydroxyethylation by N-nitrosomethylethylamine and N-nitrosodiethylamine in vivo. Carcinogenesis, 7(8), 1335–1337. https://doi.org/10.1093/carcin/7.8.1335
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Abstract
At low doses, N-nitrosomethylethylamine (NMEA) selectively produces liver tumors in rats, whereas β-trideuterated NMEA also includes esophageal carcinomas under these conditions. Since deuteration is capable of retarding enzymic hydroxylation, these studies suggest that β-hydroxylation plays a significant role in the organ specificity of NMEA. To test the hypothesis that this metabolic pathway occurs in vivo to yield a hydroxyethylating intermediate, we have determined the extent of hydroxyethylation of hepatic DNA in male Fischer 344
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- von Hofe, Eric
- Kleihues, Paul
- Keefer, Larry K
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von Hofe, E., Kleihues, P., & Keefer, L. K. (1986). Extent of DNA 2-hydroxyethylation by N-nitrosomethylethylamine and N-nitrosodiethylamine in vivo. Carcinogenesis, 7(8), 1335–1337. https://doi.org/10.1093/carcin/7.8.1335
