Publication: Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial
Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial
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Bach, D. R., Korn, C. W., Vunder, J., & Bantel, A. (2018). Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial. Translational Psychiatry, 8, 157. https://doi.org/10.1038/s41398-018-0206-7
Abstract
Abstract
Abstract
Valproate is an anticonvulsant drug with strong preclinical evidence for reducing anxiety behaviour in rodents but no clear clinical evidence. To motivate clinical trials, we here investigate the use of valproate in a translational human model of anxiety behaviour. In a double-blind, randomised, placebo-controlled trial, n = 118 healthy participants played a previously validated approach/avoidance conflict computer game to measure anxiety-like behaviour, while under 400 mg valproate, under 200 mg of the established anxiolytic/anticonv
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- Bach, Dominik R
- Korn, Christoph W
- Vunder, Johanna
- Bantel, Antonia
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Bach, D. R., Korn, C. W., Vunder, J., & Bantel, A. (2018). Effect of valproate and pregabalin on human anxiety-like behaviour in a randomised controlled trial. Translational Psychiatry, 8, 157. https://doi.org/10.1038/s41398-018-0206-7
