Publication: Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression
Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression
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Wyler, L., Napoli, C. U., Ingold, B., Sulser, T., Heikenwälder, M., Schraml, P., & Moch, H. (2014). Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression. British Journal of Cancer, 110(3), 686–694. https://doi.org/10.1038/bjc.2013.755
Abstract
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Abstract
Background:The mechanisms of brain metastasis in renal cell cancer (RCC) patients are poorly understood. Chemokine and chemokine receptor expression may contribute to the predilection of RCC for brain metastasis by recruitment of monocytes/macrophages and by control or induction of vascular permeability of the blood-brain barrier.Methods:Frequency and patterns of brain metastasis were determined in 246 patients with metastatic RCC at autopsy. Expression of CXCR4, CCL7 (MCP-3), CCR2 and CD68(+) tumour-associated macrophages (TAMs) were
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- Wyler, L
- Napoli, C U
- Ingold, B
- Sulser, T
- Heikenwälder, M
- Schraml, P
- Moch, H
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Wyler, L., Napoli, C. U., Ingold, B., Sulser, T., Heikenwälder, M., Schraml, P., & Moch, H. (2014). Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression. British Journal of Cancer, 110(3), 686–694. https://doi.org/10.1038/bjc.2013.755
