Publication: Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells
Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells
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Patzer, L., Hernando, N., Ziegler, U., Beck-Schimmer, B., Biber, J., & Murer, H. (2006). Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells. Kidney International, 70(10), 1725–1734. https://doi.org/10.1038/sj.ki.5001803
Abstract
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Renal Fanconi syndrome occurs in about 1-5% of all children treated with Ifosfamide (Ifo) and impairment of renal phosphate reabsorption in about 20-30% of them. Pathophysiological mechanisms of Ifo-induced nephropathy are ill defined. The aim has been to investigate whether Ifo metabolites affect the type IIa sodium-dependent phosphate transporter (NaPi-IIa) in viable opossum kidney cells. Ifo did not influence viability of cells or NaPi-IIa-mediated transport up to 1 mM/24 h. Incubation of confluent cells with chloroacetaldehyde (CA
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- Patzer, L
- Hernando, N
- Ziegler, U
- Beck-Schimmer, B
- Biber, J
- Murer, H
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Patzer, L., Hernando, N., Ziegler, U., Beck-Schimmer, B., Biber, J., & Murer, H. (2006). Ifosfamide metabolites CAA, 4-OH-Ifo and Ifo-mustard reduce apical phosphate transport by changing NaPi-IIa in OK cells. Kidney International, 70(10), 1725–1734. https://doi.org/10.1038/sj.ki.5001803
