Expression of Indoleamine 2,3-Dioxygenase Induced by IFN-γ and TNF-α as Potential Biomarker of Prostate Cancer Progression

Banzola, Irina; Mengus, Chantal; Wyler, Stephen; Hudolin, Tvrko; Manzella, Gabriele; Chiarugi, Alberto; Boldorini, Renzo; Sais, Giovanni; Schmidli, Tobias S; Chiffi, Gabriele; Bachmann, Alexander; Sulser, Tullio; Spagnoli, Giulio C; Provenzano, Maurizio

doi:10.5167/uzh-152047

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Banzola, I., Mengus, C., Wyler, S., Hudolin, T., Manzella, G., Chiarugi, A., Boldorini, R., Sais, G., Schmidli, T. S., Chiffi, G., Bachmann, A., Sulser, T., Spagnoli, G. C., & Provenzano, M. (2018). Expression of Indoleamine 2,3-Dioxygenase Induced by IFN-γ and TNF-α as Potential Biomarker of Prostate Cancer Progression. Frontiers in Immunology, 9:1051. https://doi.org/10.3389/fimmu.2018.01051

Abstract

Inflammation has been suggested to play an important role in onset and progression of prostate cancer (PCa). Histological analysis of prostatectomy specimens has revealed focal inflammation in early stage lesions of this malignancy. We addressed the role of inflammatory stimuli in the release of PCa-specific, tumor-derived soluble factors (PCa-TDSFs) already reported to be mediators of PCa morbidity, such as indoleamine 2,3-dioxygenase (IDO) and interleukin (IL)-6. Inflammation-driven production and functions of PCa-TDFSs were tested