Publication: Nonstable staphylococcus aureus small-colony variants are induced by low pH and sensitized to antimicrobial therapy by phagolysosomal alkalinization
Nonstable staphylococcus aureus small-colony variants are induced by low pH and sensitized to antimicrobial therapy by phagolysosomal alkalinization
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Leimer, N., Rachmühl, C., Palheiros Marques, M., Bahlmann, A. S., Furrer, A., Eichenseher, F., Seidl, K., Matt, U., Loessner, M. J., Schuepbach, R. A., & Zinkernagel, A. S. (2016). Nonstable staphylococcus aureus small-colony variants are induced by low pH and sensitized to antimicrobial therapy by phagolysosomal alkalinization. Journal of Infectious Diseases, 213, 305–313. https://doi.org/10.1093/infdis/jiv388
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BACKGROUND: Staphylococcus aureus-infected patients treated with antibiotics that are effective in vitro often experience relapse of infection because the bacteria hide in privileged locations. These locations include abscesses and host cells, which contain low-pH compartments and are sites from which nonstable S. aureus small-colony variants (SCVs) are frequently recovered. METHODS: We assessed the effect of low pH on S. aureus colony phenotype and bacterial growth, using in vitro and in vivo models of long-term infection. RESULTS: W
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- Leimer, Nadja
- Rachmühl, Carole
- Palheiros Marques, Miguel
- Bahlmann, Anna Sophie
- Furrer, Alexandra
- Eichenseher, Fritz
- Seidl, Kati
- Matt, Ulrich
- Loessner, Martin J
- Schuepbach, Reto A
- Zinkernagel, Annelies S
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Leimer, N., Rachmühl, C., Palheiros Marques, M., Bahlmann, A. S., Furrer, A., Eichenseher, F., Seidl, K., Matt, U., Loessner, M. J., Schuepbach, R. A., & Zinkernagel, A. S. (2016). Nonstable staphylococcus aureus small-colony variants are induced by low pH and sensitized to antimicrobial therapy by phagolysosomal alkalinization. Journal of Infectious Diseases, 213, 305–313. https://doi.org/10.1093/infdis/jiv388
