Publication: Evolutionary plasticity and innovations in complex metabolic reaction networks
Evolutionary plasticity and innovations in complex metabolic reaction networks
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Matias Rodrigues, J. F., & Wagner, A. (2009). Evolutionary plasticity and innovations in complex metabolic reaction networks. PLoS Computational Biology, 5, e1000613. https://doi.org/10.1371/journal.pcbi.1000613
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Genome-scale metabolic networks are highly robust to the elimination of enzyme-coding genes. Their structure can evolve rapidly through mutations that eliminate such genes and through horizontal gene transfer that adds new enzyme-coding genes. Using flux balance analysis we study a vast space of metabolic network genotypes and their relationship to metabolic phenotypes, the ability to sustain life in an environment defined by an available spectrum of carbon sources. Two such networks typically differ in most of their reactions and hav
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- Matias Rodrigues, J F
- Wagner, A
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Matias Rodrigues, J. F., & Wagner, A. (2009). Evolutionary plasticity and innovations in complex metabolic reaction networks. PLoS Computational Biology, 5, e1000613. https://doi.org/10.1371/journal.pcbi.1000613
