Publication: The local molecular signature of human peripheral neuropathic pain
The local molecular signature of human peripheral neuropathic pain
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Sandy-Hindmarch, O. P., Chang, P.-S., Scheuren, P. S., De Schoenmacker, I., Hubli, M., Loizou, C., Wirth, S., Mahadevan, D., Wiberg, A., Furniss, D., Calvo, M., Bennett, D. L. H., Denk, F., Baskozos, G., & Schmid, A. B. (2025). The local molecular signature of human peripheral neuropathic pain. Pain, 166, 1143–1156. https://doi.org/10.1097/j.pain.0000000000003472
Abstract
Abstract
Abstract
Focal nerve injuries are often associated with neuropathic pain. Preclinical research suggests altered neuroimmune signalling underlies such neuropathic pain; however, its cause remains poorly understood in humans. In this multicentre cohort study, we describe the local cellular and molecular signature of neuropathic pain at the lesion site, using Morton's neuroma as a human model system of neuropathic pain (n = 22; 18 women) compared with nerves from participants without nerve injury (n = 11; 4 women). Immunofluorescent staining reve
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Creators (Authors)
- Sandy-Hindmarch, Oliver P
- Chang, Pao-Sheng
- Scheuren, Paulina S
- De Schoenmacker, Iara
- Hubli, Michèle
- Loizou, Constantinos
- Wirth, Stephan
- Mahadevan, Devendra
- Wiberg, Akira
- Furniss, Dominic
- Calvo, Margarita
- Bennett, David L H
- Denk, Franziska
- Baskozos, Georgios
- Schmid, Annina B
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Sandy-Hindmarch, O. P., Chang, P.-S., Scheuren, P. S., De Schoenmacker, I., Hubli, M., Loizou, C., Wirth, S., Mahadevan, D., Wiberg, A., Furniss, D., Calvo, M., Bennett, D. L. H., Denk, F., Baskozos, G., & Schmid, A. B. (2025). The local molecular signature of human peripheral neuropathic pain. Pain, 166, 1143–1156. https://doi.org/10.1097/j.pain.0000000000003472
