Publication: Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial
Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial
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Walther, A., Eggenberger, L., Debelak, R., Kirschbaum, C., Häberling, I., Osuna, E., Strumberger, M. A., Walitza, S., Baumgartner, J., Herter-Aeberli, I., & Berger, G. E. (2025). Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial. Translational Psychiatry, 15(1), 183. https://doi.org/10.1038/s41398-025-03401-8
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Pediatric major depressive disorder (MDD) represents a leading cause of disability worldwide in children and adolescents, while its underlying pathophysiology remains largely elusive. The endocannabinoid system (ECS) and the hypothalamus-pituitary-adrenal (HPA) axis are considered intertwined regulatory systems crucially implicated in the pathophysiology of depressive disorders. This study explores the cross-sectional and longitudinal association between the ECS, specifically anandamide (AEA), and the HPA axis with its main effector c
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Walther, A., Eggenberger, L., Debelak, R., Kirschbaum, C., Häberling, I., Osuna, E., Strumberger, M. A., Walitza, S., Baumgartner, J., Herter-Aeberli, I., & Berger, G. E. (2025). Major depressive disorder in children and adolescents is associated with reduced hair cortisol and anandamide (AEA): cross-sectional and longitudinal evidence from a large randomized clinical trial. Translational Psychiatry, 15(1), 183. https://doi.org/10.1038/s41398-025-03401-8
