Publication: Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation
Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation
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Gay, M. H.-P., Valenta, T., Herr, P., Paratore-Hari, L., Basler, K., & Sommer, L. (2015). Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biology, 13(24), online. https://doi.org/10.1186/s12915-015-0134-4
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BACKGROUND: β-catenin plays a central role in multiple developmental processes. However, it has been difficult to study its pleiotropic effects, because of the dual capacity of β-catenin to coordinate cadherin-dependent cell adhesion and to act as a component of Wnt signal transduction. To distinguish between the divergent functions of β-catenin during peripheral nervous system development, we made use of a mutant allele of β-catenin that can mediate adhesion but not Wnt-induced TCF transcriptional activation. This allele was combined
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Gay, M. H.-P., Valenta, T., Herr, P., Paratore-Hari, L., Basler, K., & Sommer, L. (2015). Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biology, 13(24), online. https://doi.org/10.1186/s12915-015-0134-4