Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets

Postema, Merel C; Hoogman, Martine; Ambrosino, Sara; et al; Brandeis, Daniel; Brem, Silvia; O'Gorman Tuura, Ruth L; Walitza, Susanne

doi:10.1111/jcpp.13396

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Postema, M. C., Hoogman, M., Ambrosino, S., et al, Brandeis, D., Brem, S., O’Gorman Tuura, R. L., & Walitza, S. (2021). Analysis of structural brain asymmetries in attention-deficit/hyperactivity disorder in 39 datasets. Journal of Child Psychology and Psychiatry, 62(10), 1202–1219. https://doi.org/10.1111/jcpp.13396

Abstract

OBJECTIVE: Some studies have suggested alterations of structural brain asymmetry in attention-deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left-right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium. METHODS: We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilater