The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier

Sugano, Yuya; Lindenmeyer, Maja T; Auberger, Ines; Ziegler, Urs; Segerer, Stephan; Cohen, Clemens D; Neuhauss, Stephan C F; Loffing, Johannes

doi:10.1038/ki.2015.197

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Sugano, Y., Lindenmeyer, M. T., Auberger, I., Ziegler, U., Segerer, S., Cohen, C. D., Neuhauss, S. C. F., & Loffing, J. (2015). The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier. Kidney International, 88, 1047–1056. https://doi.org/10.1038/ki.2015.197

Abstract

Podocyte dysfunction impairs the size selectivity of the glomerular filter, leading to proteinuria, hypoalbuminuria, and edema, clinically defined as nephrotic syndrome. Hereditary forms of nephrotic syndrome are linked to mutations in podocyte-specific genes. To identify genes contributing to podocyte dysfunction in acquired nephrotic syndrome, we studied human glomerular gene expression data sets for glomerular-enriched gene transcripts differentially regulated between pretransplant biopsy samples and biopsies from patients with nep