Publication: Paracrine Placental Growth Factor Signaling in Response to Ionizing Radiation Is p53-Dependent and Contributes to Radioresistance
Paracrine Placental Growth Factor Signaling in Response to Ionizing Radiation Is p53-Dependent and Contributes to Radioresistance
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Kazimova, T., Tschanz, F., Sharma, A., Telarovic, I., Wachtel, M., Pedot, G., Schäfer, B., & Pruschy, M. (2021). Paracrine Placental Growth Factor Signaling in Response to Ionizing Radiation Is p53-Dependent and Contributes to Radioresistance. Molecular Cancer Research, 19(6), 1051–1062. https://doi.org/10.1158/1541-7786.MCR-20-0403
Abstract
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Abstract
Placental growth factor (PlGF) is a pro-angiogenic, N-glycosylated growth factor, which is secreted under pathologic situations. Here, we investigated the regulation of PlGF in response to ionizing radiation (IR) and its role for tumor angiogenesis and radiosensitivity. Secretion and expression of PlGF was induced in multiple tumor cell lines (medulloblastoma, colon and lung adenocarcinoma) in response to irradiation in a dose- and time-dependent manner. Early upregulation of PlGF expression and secretion in response to irradiation wa
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- Kazimova, Tamara
- Tschanz, Fabienne
- Sharma, Ashish
- Wachtel, Marco
- Pedot, Gloria
- Schäfer, Beat
- Pruschy, Martin
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Kazimova, T., Tschanz, F., Sharma, A., Telarovic, I., Wachtel, M., Pedot, G., Schäfer, B., & Pruschy, M. (2021). Paracrine Placental Growth Factor Signaling in Response to Ionizing Radiation Is p53-Dependent and Contributes to Radioresistance. Molecular Cancer Research, 19(6), 1051–1062. https://doi.org/10.1158/1541-7786.MCR-20-0403
