Publication: Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation
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Carbajal-Contreras, H., Murillo-de-Ozores, A. R., Magaña-Avila, G., Marquez-Salinas, A., Bourqui, L., Tellez-Sutterlin, M., Bahena-Lopez, J. P., Cortes-Arroyo, E., González-Behn-Eschemburg, S., Lopez-Saavedra, A., Vazquez, N., Ellison, D. H., Loffing, J., Gamba, G., & Castañeda-Bueno, M. (2024). Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation. American Journal of Physiology : Renal Physiology, 326(2), F285–F299. https://doi.org/10.1152/ajprenal.00343.2023
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Vasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway, upregulates the activity and phosphorylation of the Na+-Cl- cotransporter (NCC) and Na+-K+-2Cl- cotransporter 2 (NKCC2) by Ste20-related Proline/Alanine rich Kinase (SPAK) and Oxidative Stress Responsive kinase 1 (OSR1), which are regulated by the With No Lysine (K) kinase (WNK) family. Phosphorylation of WNK4 at PKA consensus motifs may be involved. Inhibitor 1
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Carbajal-Contreras, H., Murillo-de-Ozores, A. R., Magaña-Avila, G., Marquez-Salinas, A., Bourqui, L., Tellez-Sutterlin, M., Bahena-Lopez, J. P., Cortes-Arroyo, E., González-Behn-Eschemburg, S., Lopez-Saavedra, A., Vazquez, N., Ellison, D. H., Loffing, J., Gamba, G., & Castañeda-Bueno, M. (2024). Arginine Vasopressin regulates the renal Na-Cl and Na-K-Cl Cotransporters through With-No-Lysine Kinase 4 and Inhibitor 1 Phosphorylation. American Journal of Physiology : Renal Physiology, 326(2), F285–F299. https://doi.org/10.1152/ajprenal.00343.2023
