Obstructive sleep apnea and quality of life in Fabry disease: a prospective parallel cohort study

Gaisl, Thomas; Nowak, Albina; Sievi, Noriane A; Gerard, Nicolas; Clarenbach, Christian F; Kohler, Malcolm; Franzen, Daniel

doi:10.1007/s11325-019-01832-4

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Gaisl, T., Nowak, A., Sievi, N. A., Gerard, N., Clarenbach, C. F., Kohler, M., & Franzen, D. (2020). Obstructive sleep apnea and quality of life in Fabry disease: a prospective parallel cohort study. Sleep & Breathing = Schlaf & Atmung, 24(1), 95–101. https://doi.org/10.1007/s11325-019-01832-4

Abstract

STUDY OBJECTIVES Patients with Fabry disease (FD) report impaired quality of life and excessive daytime sleepiness. Obstructive sleep apnea (OSA) is frequently reported among patients with FD; however, its prevalence and its influence on quality of life and daytime sleepiness in this population are unclear. METHODS Patients with FD in a cohort from the University Hospital Zurich (n = 52) were one-to-two matched to healthy adult controls (n = 104) according to age, sex, and body mass index. Participants underwent structured interviews