Publication: Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential
Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential
Date
Date
Date
Citations
Liu, H., He, Z., April, S. L., Trefny, M. P., Rougier, J.-S., Salemi, S., Olariu, R., Widmer, H. R., & Simon, H.-U. (2019). Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential. Cell Death and Differentiation, 26(6), 1048–1061. https://doi.org/10.1038/s41418-018-0182-8
Abstract
Abstract
Abstract
Stem cells are generally believed to contain a small number of mitochondria, thus accounting for their glycolytic phenotype. We demonstrate here, however, that despite an indispensable glucose dependency, human dermal stem cells (hDSCs) contain very numerous mitochondria. Interestingly, these stem cells segregate into two distinct subpopulations. One exhibits high, the other low-mitochondrial membrane potentials (ψ). We have made the same observations with mouse neural stem cells (mNSCs) which serve here as a complementary model to hD
Metrics
Views
Additional indexing
Creators (Authors)
- Liu, He
- He, Zhaoyue
- April, Simon Leonhard
- Trefny, Marcel Philipp
- Rougier, Jean-Sébastien
- Salemi, Souzan
- Olariu, Radu
- Widmer, Hans Rudolf
- Simon, Hans-Uwe
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Views
Citations
Liu, H., He, Z., April, S. L., Trefny, M. P., Rougier, J.-S., Salemi, S., Olariu, R., Widmer, H. R., & Simon, H.-U. (2019). Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential. Cell Death and Differentiation, 26(6), 1048–1061. https://doi.org/10.1038/s41418-018-0182-8